HIV immunity and other fun science

First of all, one of the newest and most exciting studies at curing and preventing HIV permanently has begun today at UPenn (I believe).

From Wired (via TrevorHoppe, via Joe. My. God.):

Gene therapy that could immunize people against the most common type of HIV is ready to be tested on humans.

ruiting for the trial began Tuesday, and the first people to receive the experimental treatment will be HIV patients with drug-resistance problems.

"We do have good treatments for HIV. That has been one of the most successful stories of the last 20 years in medicine," said Pablo Tebas, an infectious disease expert at the University of Pennsylvania.

"However, over time, if the medications are not taken properly, individuals develop resistance to the HIV treatments, so they tend to have more limited therapeutic options."

Since the discovery that a small portion of people who are exposed to HIV do not get infected, scientists have been working to discover the secret to those people's resistance and how to make others resistant as well.

It turns out that most people have a gene called CCR5, which makes them vulnerable to HIV infections. The naturally resistant people have mutant CCR5 genes that inhibit HIV.

Previously, scientists found that by cutting the CCR5 gene out of white blood cells involved in the immune response known as T-cells, they could protect a tube full of human cells from the virus. The gene editing technique relies on proteins called zinc finger nucleases that can delete any gene from a living cell.

In theory, zinc finger nucleases could give that immunity to anyone.

The procedure is simple: Take some healthy T-cells out of an HIV patient, clip out their CCR5 genes, grow more of these clipped T-cells in a dish, and then put them back in the patient.

"In this first study we will re-infuse approximately 10 billion of these cells back into the participants, and we will see if it is safe and if those cells inhibit HIV replication in vivo," said Tebas. "We know they do in the test tube."

I will buy dinner to the first person who can find out how the crazy right-wingers are going to turn this into a cloning, abortion, etc. argument. (The only argument I will not accept is this: AIDS cures people of they gay... I'm sure Fred Phelps has already said that enough, so let's just let sleeping assholes lie.)

Second exciting bit of news, which should a lot for HIV-positive people's sex lives, via Wisdom of Whores (a great book!!!), via Cuddling on the Wild Side:

Public health types are always agonising about oral sex. Should we say it’s dangerous or not? Now, Swedish researchers have shown that lots of oral sex with an HIV-infected partner may actually be protective against the virus.

The study, published in the (expensive, subscription only) AIDS journal and helpfully summarised by Aidsmap suggests that men who give lots of blow jobs to their HIV-positive partners develop antibodies specific to that partner’s virus, protecting themselves against infection. The more virus their partner has kicking around in their semen, the higher the concentration of specific antibodies, and the protection seems to last for quite a while too. None of the men became infected over the course of the study, even though their partners were not all on treatment.

I’ve never been one for warning people off oral sex — while it is not 100 percent risk free it’s almost always safer than any of the alternatives that provide as much fun. But I’d hate to lose my agonised public health type credentials entirely, so I’ll point out a caveat in this study. The couples who were recruited, an infected man with an uninfected partner, had to have been together for at least 6 months — beyond the most dangerous period for infection in most cases. Any guys who did get HIV through oral sex in that risky early part of their relationship wouldn’t be in the study, because they would no longer be in a “discordant” relationship.

I'll say this about oral sex, as a "public health type:" the reason we agonize over oral sex is simple. Long again, when I worked at Planned Parenthood, my NP had an argument that I didn't agree with at the time but one I get now: we shouldn't cure HIV because there needs to be something we are scared of out there. With oral sex, though there are no conclusive proving transmissability via oral sex, and the cases are anecdotal and prove nothing, it would be irresponsible to say that "oral sex transmits HIV" because we're pretty sure it doesn't.

However, oral sex isn't safe sex, it's safer, yes, but that's it. You can still get herpes, gonorrhea (common), chlamydia (rare), and syphilis pretty easily from unprotected oral sex (u/oSIC as I document it, verses u/arSIC or u/aiSIC or u/vSIC). But if you start telling people that you can't get HIV from oral sex, then they start thinking it's perfectly safe.

And, like Saddlebacking, people start thinking that it's perfectly fine.

That said... this is really good news for serodiscordant couples and their sex lives, and ten times more relevant than serosorting.

Saddlebacking -- DEFINED!!!

IMG thanks to Towleroad
For the whole story, visit Dan Savage's column.

Dan Savage is at it again...

Once upon a time, Dan Savage redefined god-awful, gay-hating Sen. Rick Santorum's last name to mean "The sometimes frothy, usually slimy, amalgam of lubricant, stray fecal matter, and ejaculate that leaks out of the receiving partner's anus after a session of anal intercourse. Named, by popular demand and usage, after legislator Rick Santorum because of his homophobic political statements." (Thanks to the Urban Dictionary for that.)

And now he wants to do the same for Rick Warren's church, Saddleback Church. So what, do you think, should be the definition of "Saddlebacking?" These are the finalists:

(1) "Logically, if 'barebacking' means having butt sex with no condom, then 'saddlebacking' should mean having butt sex with a condom."

(2) "Saddleback (verb): to submit someone to any kind of humiliating, unreciprocal sex act, either literally or metaphorically, consented to by passive partner due to submissive/masochistic tendencies, desire for approval, or other darker motive. E.g., 'I don't know why Obama is letting Rick Warren saddleback him into presiding over his inauguration.'"

(3) "The saddleback position involves placing your lubed dick between the butt cheeks of your partner. This position can be performed on your sides or on top of a facedown partner (maybe with a pillow under his or her hips). My favorite way of finishing up the saddlebacking is to lift up and come on my wife's sweaty back. The saddleback is a nice compromise position when your partner won't allow anal entry."

(4) "To saddleback is to rail against gay sex in public while secretly indulging in the same in private. Ted Haggard? Total saddlebacker. Larry Craig? Saddlebacker. Rick Warren? Probably a saddlebacker."

(5) "'Saddlebacking' should be the term for the phenomenon of Christian teens engaging in unprotected anal sex in order to preserve their virginities. 'After attending the Purity Ball, Heather and Bill saddlebacked all night because she's saving herself for marriage.' Please, please adopt this definition!"

(6) "Saddleback (verb): to ejaculate on the back of a partner at the culmination of doggy-style anal sex."

(7) "Before being invited to give the invocation, Mr. Warren was most noted for his book The Purpose Driven Life. Therefore, 'to saddleback' is to fuck with a purpose, i.e., to procreate. A heterosexual couple asked if they're trying to have children could reply, 'No, we're not ready for kids yet, but we'll probably start saddlebacking next year.'"

I'm voting for number one, because it's about time we had an answer to the term "barebacking." Right? Why not Saddlebacking. My email is going in right now. Make sure you email your preference to: saddleback@savagelove.net. Yea, yea, there are some more "poetically ironic" ones. But who would commonly use the other ones?

Thanks to Joe. My. God. for pointing this out.

PS My cat is lovable, sweet, and wonderful.. but needy. Anyone want her? Her name is Jezebel. You should find the irony sweet.