This is the most hotly debated constitutional amendment in the state, and there are some interesting arguments either way and I'm not fully convinced on my own position here, but I'm goign to say this:

Why? Not because this particular casino is the best thing in the world. In fact, I would argue it's probably not. The
amendment is written strangely and, even though I'm no legal scholar, I can definitely see the argument that it's possible, in the future, the taxes could be lowered to zero. But make sure you read exactly what is being said: it
could be lowered, and it's
possible.
Not that it is.
Here's my point: how many times has Ohio been given the opportunity to move forward? We've said no to slot machines before -- for the love of god -- and we've said no to public transportation -- which is silly, now -- and we've said no to gay marriage (and probably would have said no to equal rights had it come to the ballot in 2006). We keep saying no on simply going forward with our lives.
Rather, we want to wait to be the final state in the country to do anything. I think this is a chance we should take as a state. I think the huge successes of the out of state casinos should be used as a model of how beneficial this could be. After all, what does it say that Argosy is running the No on 6 campaign? Says to me that they are scared that people from Ohio will stay in Ohio.
Both sides are funded by rich businessmen. Both sides are trying to get your money one way or another.
To my mind, I would rather the money stay in Ohio. Even if the taxes go down later (which would mean more casino's have opened, which means more money, btw), there are still jobs to consider, and lets talk about peripheral businesses. Gas stations, what? Restaurants? Hotels? Other entertainment venues???
If you are so hot on economic development, this is what we call a tax break to spur development, and it's crazy that we should be opposing it just because maybe sometime in the future there may be fewer taxes generated. That's not an argument, that's a scare tactic. Even for the first year, we could see upwards of $800million or more raised from people doing nothing more than simply throwing cash at a machine. We've raised money in more complicated manners in the past.
Let's stop fighitng it, and let's grow up, Ohio.
Yes on 6.